This Commission was created to investigate the nexus of women, power, and cancer. By applying an intersectional feminist approach, it investigated, exposed, and challenged the prevailing asymmetries of power in relation to cancer in three key domains: decision making, knowledge, and economics. In this Commission report, the research team presents key findings and recommends a set of ten actions, with the overarching recommendation that sex and gender are included in all cancer-related policies and guidelines, making all policies responsive to the needs and aspirations of women in all their diversities. It aimed to advance a gender transformative approach to cancer studies. The report highlights unconscious biases in healthcare systems and calls for a transformative feminist approach.