Sexual violence and relationship abuse are prevalent among adolescent and programs promoting gender equity, reproductive justice and healthy relationships are key strategies for prevention. While such “gender transformative” approaches appear promising for boys, they have not been evaluated among girls. This study assessed the feasibility of this community-based program, called Sisterhood 2.0, among girls in socially disadvantaged urban neighborhoods in Pittsburgh, Pennsylvania. The conclusion was that community-based gender transformative programming for girls is feasible and may be a promising approach for addressing interpersonal violence and promoting sexual health.